Researchmap

 

Selected publications

1. Li, Y*., Hirayasu, K*. (*co-first authors) et al. Front. Immunol. in press

2. Hirayasu, K., Khor, S.-S., Kawai, Y., Shimada, M., Omae, Y., Hasegawa, G., Hashikawa, Y., Tanimoto, H., Ohashi, J., Hosomichi, K., Tajima, A., Nakamura, H., Nakamura, M., Tokunaga, K., Hanayama, R. & Nagasaki, M. Identification of the hybrid gene LILRB5-3 by long-read sequencing and implication of its novel signaling function. Front. Immunol. 15, 1398935 (2024).

3. Hirayasu, K., Sun, J., Hasegawa, G., Hashikawa, Y., Hosomichi, K., Tajima, A., Tokunaga, K., Ohashi, J. & Hanayama, R. Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population. J Hum Genet 66, 739–748 (2021).

4. Hirayasu, K. & Arase, H. Leukocyte Immunoglobulin-Like Receptor (LILR). Encyclopedia of Signaling Molecules 2nd Edition, (2018).

5. Deng, M., Gui, X., Kim, J., Xie, L., Chen, W., Li, Z., He, L., Chen, Y., Chen, H., Luo, W., Lu, Z., Xie, J., Churchill, H., Xu, Y., Zhou, Z., Wu, G., Yu, C., John, S., Hirayasu, K., Nguyen, N., Liu, X., Huang, F., Li, L., Deng, H., Tang, H., Sadek, A. H., Zhang, L., Huang, T., Zou, Y., Chen, B., Zhu, H., Arase, H., Xia, N., Jiang, Y., Collins, R., You, M. J., Homsi, J., Unni, N., Lewis, C., Chen, G.-Q., Fu, Y.-X., Liao, X. C., An, Z., Zheng, J., Zhang, N. & Zhang, C. C. LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. Nature 562, 605–609 (2018).

6. Saito, F*., Hirayasu, K*. (*co-first authors), Satoh, T., Wang, C. W., Lusingu, J., Arimori, T., Shida, K., Palacpac, N. M. Q., Itagaki, S., Iwanaga, S., Takashima, E., Tsuboi, T., Kohyama, M., Suenaga, T., Colonna, M., Takagi, J., Lavstsen, T., Horii, T. & Arase, H. Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors. Nature 552, 101–105 (2017).

7. Hirayasu, K., Saito, F., Suenaga, T., Shida, K., Arase, N., Oikawa, K., Yamaoka, T., Murota, H., Chibana, H., Nakagawa, I., Kubori, T., Nagai, H., Nakamaru, Y., Katayama, I., Colonna, M. & Arase, H. Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2. Nat Microbiol 1, 16054 (2016).

8. Hirayasu, K. & Arase, H. Functional and genetic diversity of leukocyte immunoglobulin-like receptor and implication for disease associations. J Hum Genet 60, 703–8 (2015).

9. Hirayasu, K., Ohashi, J., Kashiwase, K., Hananantachai, H., Naka, I., Ogawa, A., Takanashi, M., Satake, M., Nakajima, K., Parham, P., Arase, H., Tokunaga, K., Patarapotikul, J. & Yabe, T. Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA. PLoS Pathog 8, e1002565 (2012).

10. Yabe, T., Matsuo, K., Hirayasu, K., Kasbiwase, K., Kawamura-Ishii, S., Tanaka, H., Ogawa, A., Takanshi, M., Satake, M., Nakajima, K., Tokunaga, K., Inoko, H., Saji, H., Ogawa, S., Juji, T., Sasazuki, T., Kodera, Y. & Morishima, Y. Donor killer immunoglobulin-like receptor (KIR) genotype-patient cognate KIR ligand combination and antithymocyte globulin preadministration are critical factors in outcome of HLA-C-KIR ligand-mismatched T cell-replete unrelated bone marrow transplantation. Biol Blood Marrow Transplant 14, 75–87 (2008).

11. Hirayasu, K., Ohashi, J., Tanaka, H., Kashiwase, K., Ogawa, A., Takanashi, M., Satake, M., Jia, G. J., Chimge, N. O., Sideltseva, E. W., Tokunaga, K. & Yabe, T. Evidence for natural selection on leukocyte immunoglobulin-like receptors for HLA class I in Northeast Asians. Am J Hum Genet 82, 1075–83 (2008).

12. Hirayasu, K., Ohashi, J., Kashiwase, K., Takanashi, M., Satake, M., Tokunaga, K. & Yabe, T. Long-term persistence of both functional and non-functional alleles at the leukocyte immunoglobulin-like receptor A3 (LILRA3) locus suggests balancing selection. Hum Genet 119, 436–43 (2006).